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KMID : 1094720220270010111
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Biotechnology and Bioprocess Engineering
2022 Volume.27 No. 1 p.111 ~ p.118
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Study of the Extraction Kinetics and Calculation of Effective Diffusivity and Mass Transfer Coefficient in Negative Pressure Cavitation Extraction of Paclitaxel from Taxus chinensis
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Min Hye-Su
Kim Jin-Hyun
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Abstract
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In this study, the recovery efficiency of paclitaxel from Taxus chinensis was remarkably improved through negative pressure cavitation extraction. Most of the paclitaxel could be recovered from the biomass at a negative pressure of ?260 mmHg with a one-time extraction in a short operating time (10?20 min). The pseudo-second-order model was suitable for the kinetic analysis, and the diffusion of paclitaxel in the biomass played a dominant role in the overall extraction rate according to the intraparticle diffusion model. As the negative pressure increased (0, ?160, and ?260 mmHg), the extraction rate constant (4.3325?5.9126 mL/mg·min), the effective diffusion coefficient (1.083 × 10?12 ? 1.377 × 10?12 m2/s), and the mass transfer coefficient (1.428 × 10?7 ? 2.371 × 10?7 m/s) increased.
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KEYWORD
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paclitaxel, extraction, negative pressure, cavitation, mass transfer kinetics
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